At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Carry out laboratory functions, plan and design experiments, and apply technical knowledge and skills to achieve project goals in a precise and timely manner

• Design, synthesize, and characterize antibody conjugates using state-of-the-art bioconjugation methods, purification processes, and biophysical techniques

• Optimized conjugation protocols using novel chemistries and techniques for a variety of bioconjugates modalities such as peptide-antibody (APC), oligonucleotides-antibody (AOC) and small molecule antibody (ADC) conjugates. Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is desirable

• Identify and troubleshoot critical issues within conjugation processes, resolving them promptly to ensure consistent progress and quality

• Collaborate cross-functionally with chemists and other teams to design and establish linker-payload biologic SAR (structure-activity relationships), supporting scientific discovery and project progression

• Tracks progress against the timelines of ongoing projects, ensuring timely delivery of results and providing regular updates to project teams and stakeholders

• Effective communication of scientific rationale, results, and interpretation at project, team and departmental meetings, contributing to strategic discussions

• Establish and maintain excellent working relationships with critical collaborators throughout the company

• Maintains accurate and well-organized lab notebooks and batch records to document all experimental procedures and findings, ensuring compliance with regulatory requirements and internal standards

• BS/BA degree in biology and 2+ years of relevant experience OR

• MS/MA degree in biology and some relevant industry experience preferred OR

• PhD or equivalent and Some relevant experience

• In-depth knowledge of modern protein bioconjugation (peptide, protein, and antibody) purification, and analytical characterization

• Hands-on experience with antibody conjugates with various payload classes, including peptides, oligonucleotides, and small molecules. Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is an advantage

• Strong background in analytical characterization of bioconjugates, specifically RP-HPLC, LC-MS

• Proficiency in purification techniques for antibodies and antibody conjugates such as RP-HPLC, FPLC-AKTA, size-exclusion (SEC), ion exchange (IEX), tangential flow filtration (TFF)

• Independently design and implement conjugation and purification strategies applying stay-of-the-art knowledge in the field

• Strong publication record of accomplishment

• Understanding of peptide, siRNA, and protein structure and associated biophysical techniques to assess structure, stability, and behavior in solution is desirable

• Experience in formulation strategies for conjugate molecules is a plus

• Experience with siRNA design/synthesis is a plus

• Excellent interpersonal skills with strong oral and written communication abilities

• Assimilates data and research findings outside of Neurocrine and applies them to new scientific projects

• Prioritizes teamwork above all else

• Excellent computer, communications, problem-solving, and analytical thinking skills

• Ability to meet multiple deadlines across a variety of projects/programs with a high degree of accuracy and efficiency

• Must be able to work independently with supervision as needed

• Understands the team's role within the larger organization and can discuss changes, progress, and issues in relation to other areas

• Maintains a comprehensive knowledge of principles and theories, providing solutions to a wide range of complex problems

• Ability to work as part of a teams

• Possesses excellent communication skills and can effectively present complex scientific data

• Demonstrates strong problem-solving and analytical thinking skills, showing a proactive attitude towards exploring new approaches

• Able to meet multiple deadlines across various projects/programs with a high degree of accuracy and efficiency

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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